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Does hydroxyurea cause leukemia? Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow. This may increase the risk that you will develop a serious infection or bleeding. Hydroxyurea may increase the risk that you will develop other cancers, including skin cancer.
How safe is hydroxyurea? Hydroxyurea is very safe when given by medical specialists experienced in caring for patients with sickle cell disease. But, an increased risk of cancer has not been found in children and adults with sickle cell disease. Some of these patients have been treated with hydroxyurea for as long as 15 years.
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